study of a new method in treatment of term newborns with non-hemolytic hyperbilirubinemia

The purpose of the study was to determine whether reduction of serum levels of bilirubin is more in full-term newborn with non-hemolytic hvperbilirubinemia that treated with new treatment than in matched control subjects. Eighty consecutively admitted term health neonate with indirect hvperbilirubinemia and indication for phototherapy were randomized into receiving phenobarbital [3 mg/kg/day] plus phototherapy as new treatment method or phototherapy as routine method after obtaining intformed consent. The neonate followed up until discharge. The total serum bilirubin levels were measured four times a day. Patient's data regarding variation of bilirubin and hospitalization duration collected and compared from the two groups. Results are presented as the mean, 95% confidence interval, 0.05% significance level and 80% power The baseline characteristics were similar in two groups. Mean ages were 5.5 +/- 2.81 and 4.80 +/- 1.68 days for control and case group respectively. Mean bilirubin levels in admission were l 9.48 +/- 2.80 mg/dl and 18.51 +/- 166 for control and case group respectively. There was significant reduction of bilirubin levels in case group compared to control group [10.54 +/- 3.00 mg/dl versus 8.60 +/- 1.99 mg/dl] [P=0.001]. No significant difference with respect to duration of hospitalization was observed in two groups' [2.05 +/- 0.59 days for control versus, 2.15 +/- 0.80 days for case group]. In despite of significant reduction of bilirubin levels in case group compared to control group, combined treatment is not helpful in reducing of hospitalization days of non-hemolytic hyperbilirubinemia in healthy term neonates

Evaluation of androgen and progesterone levels of women with preeclampsia in third trimester

The purpose of the study was to determine whether maternal serum levels of androgen and progesterone, are higher in patient with preeclampsia than in matched control subjects. Serum progesterone, total testosterone, free testosterone and dehydroepiandrosterone levels were measured in 19 subjects in third trimester of pregnancy with documented preeclampsia and 17 healthy normotensive women with similar maternal and gestational ages. All subjects were primigravida women with singleton pregnancy who were visited in Kosar Medical center in Uromiyeh. There were no significant differences between two groups in maternal age, gestational age and body mass index. Progesterone and free testosterone levels were significantly lower [p=0.01] in patients with preeclampsia [75.1 +/- 8.6 ng/dL and 2.27 +/- 1.71 pg/dL, respectively] than in control group [111.6 +/- 9.71 ng/dL and 3.73 +/- 1.31 pg/dL, respectively]. There were no significant differences in total testosterone and dehydroepiandrosterone levels between cases [1.02 +/- 0.10 ng/dL and 0.99 +/- 0.13 micro g/dL, respectively] and controls [1.37 +/- .019 ng/dL and 0.98 micro 5.15 micro g/dL, respectively]. Accentuated sex hormone binding globulin increase in preeclampsia is the cause of significant decreased free testosterone of preeclamptic cases. Levels of progesterone were pathologically and significantly lower in preeclamptic cases than control women with similar age, gestational age and body mass index. This difference raises the possibility for a role of progesterone in the pathogenesis of preeclampsia